PI3K inhibitor PP121, Purity ≥98%

Synonym: 1092788-83-4; PP-121; PI3K inhibitor

CAS Number: 1092788-83-4
Compound CID: 24905142

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PP121, soluble in DMSO and ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets Hck, VEGFR, Abl, DNA-PK, EGFR, EphB4, mTOR, p110α, p110β, p110δ, and p110γ.

Molecular Weight

319.36

Molecular Formula

C₁₇H₁₇N₇

Targets

Hck: 8 nM; VEGFR: 12 nM; Abl: 18 nM; DNA-PK: 60 nM; EGFR: 260 nM; EphB4: 190 nM; mTOR: 13 nM; p110α: 52 nM; p110β: 1.4 μM; p110δ: 150 μM; p110γ: 1.1 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 63 mg/mL (197.27 mM); Water: Insoluble; Ethanol: 2 mg/mL (6.26 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

PP121 can be used to study the inhibition of multiple PI3K isoforms and its downstream effects on cancer cell growth and survival.