PI3K inhibitor PP121, Purity ≥98%

Synonym: 1092788-83-4; PP-121; PI3K inhibitor

CAS Number: 1092788-83-4
Compound CID: 24905142

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PP121, soluble in DMSO and ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets Hck, VEGFR, Abl, DNA-PK, EGFR, EphB4, mTOR, p110α, p110β, p110δ, and p110γ.

Molecular Weight

319.36

Molecular Formula

C₁₇H₁₇N₇

Targets

Hck: 8 nM; VEGFR: 12 nM; Abl: 18 nM; DNA-PK: 60 nM; EGFR: 260 nM; EphB4: 190 nM; mTOR: 13 nM; p110α: 52 nM; p110β: 1.4 μM; p110δ: 150 μM; p110γ: 1.1 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 63 mg/mL (197.27 mM); Water: Insoluble; Ethanol: 2 mg/mL (6.26 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

PP121 can be used to study the inhibition of multiple PI3K isoforms and its downstream effects on cancer cell growth and survival.

Storage

Store at -20ºC.