Properties
Description
Rigosertib sodium is a potent compound that inhibits PI3 kinase activity. It targets BCR-ABL, Cdk1, Flt1, Fyn, PDGFR, PLK1, PLK2, and Src.
Molecular Formula
C21H24NNaO8S
Targets
BCR-ABL: 32 nM; Cdk1: 260 nM; Flt1: 42 nM; Fyn: 182 nM; PDGFR: 18 nM; PLK1: 9 nM; PLK2: 260 nM; Src: 155 nM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Rigosertib sodium is used to study its inhibition of PI3K and its potential anti-cancer effects, especially in myelodysplastic syndromes.
