Properties
Description
SAR245409, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kα, PI3Kδ, DNA-PK, mTOR, PI3Kβ, and PI3Kγ.
Molecular Formula
C13H14N6O
Targets
PI3Kα: 39 nM; PI3Kδ: 43 nM; DNA-PK: 150 nM; mTOR: 157 nM; PI3Kβ: 113 nM; PI3Kγ: 9 nM
Solubility
DMSO: 53 mg/mL (196.08 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
SAR245409 can be used to explore dual inhibition of PI3K/mTOR pathways in oncology research.