PI3K inhibitor TGR-1202, Purity ≥98%

Synonym: 1532533-67-7; Umbralisib; RP5264; TGR1202; TGR 1202; RP-5264; RP 5264; PI3K inhibitor

CAS Number: 1532533-67-7
Compound CID: 72950888

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

MSDS

Properties

Description

TGR-1202, soluble in warmed DMSO and warmed ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kα, PI3Kβ, PI3Kδ, PI3Kδ, and PI3Kγ.

Molecular Weight

571.55

Molecular Formula

C₃₁H₂₄F₃N₅O₃

Targets

PI3Kα: >10000 nM (Kd); PI3Kβ: >10000 nM (Kd); PI3Kδ: 22.2 nM (EC₅₀); PI3Kδ: 6.2 nM (Kd); PI3Kγ: 1400 nM (Kd)

Form

Lyophilized powder

Purity

Solubility

Warmed DMSO: 92 mg/mL (160.96 mM); Water: Insoluble; Warmed ethanol: 6 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

TGR-1202 is used to investigate the selective inhibition of PI3Kδ and its implications in B-cell malignancies and autoimmune disorders.