Properties
Description
TGR-1202, soluble in warmed DMSO and warmed ethanol and insoluble in water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kα, PI3Kβ, PI3Kδ, PI3Kδ, and PI3Kγ.
Molecular Formula
C31H24F3N5O3
Targets
PI3Kα: >10000 nM (Kd); PI3Kβ: >10000 nM (Kd); PI3Kδ: 22.2 nM (EC50); PI3Kδ: 6.2 nM (Kd); PI3Kγ: 1400 nM (Kd)
Solubility
Warmed DMSO: 92 mg/mL (160.96 mM); Water: Insoluble; Warmed ethanol: 6 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Applications
TGR-1202 is used to investigate the selective inhibition of PI3Kδ and its implications in B-cell malignancies and autoimmune disorders.
