PI3K inhibitor TGX-221, Purity ≥98%

Synonym: 663619-89-4; TGX221; PI3K inhibitor

CAS Number: 663619-89-4
Compound CID: 9907093

Product Size

5 mg; 10mg; 25 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TGX-221, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets p110α, p110δ, Abl, C2α, CaMK, CaseinKinase2, CDK2/CyclinA, EGFR, ERK1, Fyn, and HER2.

Molecular Weight

364.4

Molecular Formula

C₂₁H₂₄N₄O₂

Targets

p110α: 5 μM; p110δ: 0.1 μM; Abl: >10 μM; C2α: >10 μM; CaMK: >10 μM; CaseinKinase2: >10 μM; CDK2/CyclinA: >10 μM; EGFR: >10 μM; ERK1: >10 μM; Fyn: >10 μM; HER2: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 11 mg/mL (30.18 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

TGX-221 is utilized to investigate the inhibition of PI3Kβ and its implications in cancer and thrombosis research.