Properties
Description
Wortmannin, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets ATM [12], ATR [12], DNA-PK [12], MLCK, and PI3K.
Molecular Formula
C23H24O8
Targets
ATM [12]: 150 nM; ATR [12]: 1.8 nM; DNA-PK [12]: 16 nM; MLCK: 170 nM; PI3K: 3 nM
Solubility
DMSO: 73 mg/mL (170.38 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Wortmannin is used to study the broad inhibition of PI3K signaling and its impact on cell growth, metabolism, and cancer.
