Properties
Description
Wortmannin, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets ATM [12], ATR [12], DNA-PK [12], MLCK, and PI3K.
Molecular Formula
C23H24O8
Targets
ATM [12]: 150 nM; ATR [12]: 1.8 nM; DNA-PK [12]: 16 nM; MLCK: 170 nM; PI3K: 3 nM
Solubility
DMSO: 73 mg/mL (170.38 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Wortmannin is used to study the broad inhibition of PI3K signaling and its impact on cell growth, metabolism, and cancer.
