Properties
Description
XL147 analogue, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kα, PI3Kδ, B-Raf/C-Raf, DNA-PK, MEK, mTOR, PI3Kβ, PI3Kγ, and Vps34.
Molecular Formula
C21H16N6O2S2
Targets
PI3Kα: 39 nM; PI3Kδ: 36 nM; B-Raf/C-Raf: >10 μM; DNA-PK: 4.75 μM; MEK: >10 μM; mTOR: >15 μM; PI3Kβ: 383 nM; PI3Kγ: 23 nM; Vps34: 6.975 μM
Solubility
DMSO: 3 mg/mL (6.68 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
XL147 analogue can be employed to study the inhibition of PI3K signaling and its therapeutic potential in cancer research.
