PI3K inhibitor XL147 analogue, Purity ≥98%

Synonym: 956958-53-5; XL-147; SAR245408; PI3K inhibitor

CAS Number: 956958-53-5
Compound CID: 1893730

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

XL147 analogue, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kα, PI3Kδ, B-Raf/C-Raf, DNA-PK, MEK, mTOR, PI3Kβ, PI3Kγ, and Vps34.

Molecular Weight

448.5

Molecular Formula

C₂₁H₁₆N₆O₂S₂

Targets

PI3Kα: 39 nM; PI3Kδ: 36 nM; B-Raf/C-Raf: >10 μM; DNA-PK: 4.75 μM; MEK: >10 μM; mTOR: >15 μM; PI3Kβ: 383 nM; PI3Kγ: 23 nM; Vps34: 6.975 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 3 mg/mL (6.68 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

XL147 analogue can be employed to study the inhibition of PI3K signaling and its therapeutic potential in cancer research.