Properties
Description
XL765, soluble in DMSO and insoluble in ethanol and water, is a potent compound that inhibits PI3 kinase activity. It targets PI3Kα, PI3Kδ, DNA-PK, mTOR, PI3Kβ, and PI3Kγ.
Molecular Formula
C31H29N5O6S
Targets
PI3Kα: 39 nM; PI3Kδ: 43 nM; DNA-PK: 150 nM; mTOR: 157 nM; PI3Kβ: 113 nM; PI3Kγ: 9 nM
Solubility
DMSO: 10 mg/mL (16.68 mM; Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
XL765 is researched for its dual inhibition of PI3K/mTOR, providing insights into the treatment of cancers dependent on these signaling pathways.
