PKC inhibitor Sotrastaurin, Purity ≥98%

Synonym: Sotrastaurin; 425637-18-9; AEB071; Sotrastaurin (AEB071); AEB-071; 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione; 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione; PKC inhibitor

CAS Number: 425637-18-9
Compound CID: 10296883

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Sotrastaurin, soluble in DMSO and ethanol and insoluble in water, acts as an ATP-competitive PKC inhibitor. It targets PKCα, PKCβ1, PKCδ, PKCε, PKCη, and PKCθ.

Molecular Weight

438.5

Molecular Formula

C₂₅H₂₂N₆O₂

Targets

PKCα: 0.95 nM (Ki); PKCβ1: 0.64 nM (Ki); PKCδ: 2.1 nM (Ki); PKCε: 3.2 nM (Ki); PKCη: 1.8 nM (Ki); PKCθ: 0.22 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 79 mg/mL (180.17 mM); Water: Insoluble; Ethanol: 2 mg/mL (4.56 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Sotrastaurin can be used to study the inhibition of protein kinase C (PKC) in various cellular signaling pathways.

Storage

Store at -20ºC.