PLK inhibitor Mps1-IN-2, Purity ≥98%

Synonym: 1228817-38-6; Mps1-IN-2; 9-Cyclopentyl-2-[2-ethoxy-4-(4-hydroxypiperidin-1-yl)anilino]-5-methyl-7,8-dihydropyrimido[4,5-b][1,4]diazepin-6-one; PLK inhibitor

CAS Number: 1228817-38-6
Compound CID: 44968267

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Mps1-IN-2 targets Polo-like kinases, which are essential regulators of cell division and mitosis, making them effective in halting the proliferation of cancer cells. It targets GAK, Mps1, PLK1, and PLK3.

Molecular Weight

480.6

Molecular Formula

C₂₆H₃₆N₆O₃

Targets

GAK: 140 nM (Kd); Mps1: 12 nM (Kd); PLK1: 61 nM (Kd); PLK3: 1600 nM (Kd)

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

Mps1-IN-2 is used to study its role in inhibiting monopolar spindle 1 kinase and its effects on chromosome segregation.