Properties
Description
Ponesimod, soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets S1P1 receptor.
Molecular Formula
C23H25ClN2O4S
Targets
S1P1 receptor: 5.7 nM (EC50)
Solubility
DMSO: 82 mg/mL (177.88 mM); Water: insoluble; Ethanol: 82 mg/mL
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Ponesimod can be used for its ability to retain certain white blood cells (lymphocytes) within the lymph nodes, thereby preventing their migration into the central nervous system where they can contribute to inflammation and damage.
Storage
Store at -20°C, and keep desiccated.
