Potassium Chloride and Glucose Injection Analysis Service

Potassium Chloride and Glucose Injection Analysis Service

Delving Deep into Solutions for Safer Research Trips with Potassium Chloride and Glucose Injection Analysis

Potassium chloride and glucose injection is a sterilized aqueous solution of potassium chloride and glucose, which is a clear colorless, or slightly yellow liquid. It belongs to the electrolyte supplementation drugs and has a good therapeutic effect on hypokalemia caused by various reasons. With rich experience in Pharmaceutical and Biological Analysis, CD BioGlyco provides clients with comprehensive potassium chloride and glucose injection analysis.

  • Potassium chloride and glucose injection identification
    We slowly add the sample to be identified to a warm alkaline copper tartrate solution and if a red cuprous oxide precipitate is produced, the sample is potassium chloride and glucose injection.
  • pH analysis
    Utilize a pH meter to measure the pH of potassium chloride and glucose injection. Theoretically, its pH should be 3.5 to 6.5.
  • Potassium chloride content analysis
    Titration: Dextrin solution and fluorescent yellow indicator solution are added to potassium chloride and glucose injection and titrated with silver nitrate solution. When the color changes, stop the titration. Calculate the mass of potassium chloride from the amount of silver nitrate used.
  • Glucose content analysis
    The mass of glucose contained in the injection is calculated by testing the spinometer of potassium chloride and glucose injection.
  • Impurity (5-hydroxymethylfurfural) analysis
    We accurately weigh a small amount of potassium chloride and glucose injection, dilute it with water, and test its absorbance using an ultraviolet-visible spectrophotometer. The absorbance of the potassium chloride and glucose injection standard should not exceed 0.25.
  • Heavy metal analysis
    Acetate buffer is added to the potassium chloride and glucose injection. The heavy metals contained in it are analyzed by comparing the color of the solution and the color of different heavy metal ion solutions respectively.
  • Osmolality molar concentration analysis
    The osmotic pressure molar concentration of potassium chloride and glucose injection is indirectly determined by measuring the decrease in freezing point of the injection, a process that is primarily accomplished using an osmotic pressure molar concentration meter.

In addition to the above analysis, we develop potassium chloride and glucose injection analysis programs according to the needs of our clients.

Fig.1 Potassium chloride and glucose injection analysis services. (CD BioGlyco)Fig.1 Potassium chloride and glucose injection analysis services. (CD BioGlyco)

Publication Data

Technology: Headspace gas chromatography (HS-GC)

Journal: Journal of Chromatography A

IF: 4.1

Published: 2017

Results: An automated technique is presented for the rapid detection of glucose content in glucose injections by reactive HS-GC. The method and core of this assay is the oxidation reaction of glucose with potassium dichromate. Within this reaction, carbon dioxide gas is produced, which can be quantitatively detected by GC. It was found that the relative standard deviation (RSD) of the technique was within 2.91% and the relative difference between the actual and measured values of glucose content in glucose injection was less than 6.45%. The HS-GC technique can be used for the batch determination of glucose contents in applications related to glucose injection.

Fig.2 Chromatogram of a glucose sample from HS-GC testing. (Xie, et al., 2017)Fig.2 Chromatogram of a glucose sample from HS-GC testing. (Xie, et al., 2017)

Advantages

  • We provide the best custom Pharmaceutical Analysis solutions and our clients can choose the most appropriate solutions and services according to their needs.
  • Our team members have different academic backgrounds and professional experiences, covering a wide range of knowledge and skill areas.
  • Our pharmaceutical analysis technology is world-leading, ensuring that every pharmaceutical analysis project is completed with high efficiency and quality.

CD BioGlyco utilizes state-of-the-art pharmaceutical analysis technologies to design appropriate analysis protocols based on our clients' needs, ensuring that drug analysis is completed efficiently and reliably. Our services will help you fully understand the characteristics and functions of each pharmaceutical product, opening up more possibilities for your research and development. If you are interested in our services, please feel free to contact us for more details.

Reference

  1. Xie, W.Q.; et al. Rapid quantitative detection of glucose content in glucose injection by reaction headspace gas chromatography. Journal of Chromatography A. 2017, 1520: 143-146.
This service is for Research Use Only, not intended for any clinical use.

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