PROTAC degrader inhibitor, ARV-771, Purity ≥98%

Synonym: 1949837-12-0; ARV771; ARV 771; (2S,4R)-1-[(2S)-2-[[2-[3-[2-[[2-[(9S)-7-(4-Chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]ethoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide; PROTAC degrader inhibitor

CAS Number: 1949837-12-0
Compound CID: 126619980

Product Size

1 mg; 5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ARV-771, soluble in DMSO and ethanol and insoluble in water, is an effective PROTAC inhibitor, that has the ability to prevent the pathway of PROTAC degrader. The molecular weight of the compound is 986.64, and its molecular formula is C₄₉H₆₀ClN₉O₇S₂. It targets the BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1) and BRD4(2).

Molecular Weight

986.64

Molecular Formula

C₄₉H₆₀ClN₉O₇S₂

Targets

BRD2 (1)

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 97 mg/mL (98.31 mM); Water: insoluble; Ethanol: 97 mg/mL (98.31 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

ARV-771 can be studied extensively for its potential therapeutic applications in the treatment of castration-resistant prostate cancer (CRPC) by eliminating the androgen receptor, which drives tumor growth in these patients.