Properties
Description
MLN9708, soluble in DMSO and insoluble in ethanol and water, interferes with the proteasome’s ability to degrade proteins, thereby disrupting cellular processes in cancer cells, particularly multiple myeloma. It targets 20S proteasome and 20S proteasome.
Molecular Formula
C20H23BCl2N2O9
Targets
20S proteasome: 0.93 nM (Ki); 20S proteasome: 3.4 nM
Solubility
DMSO: 85 mg/mL (164.36 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
MLN9708 is applied in studies focused on proteasome inhibition, which is a strategy used in cancer therapy, particularly for multiple myeloma.
