Proteasome inhibitor ONX 0912, Purity ≥98%

Synonym: 935888-69-0; Proteasome inhibitor; Oprozomib; ONX-0912; ONX0912

MDL: MFCD25976563
CAS Number: 935888-69-0
Compound CID: 25067547

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ONX 0912, soluble in DMSO and insoluble in ethanol and water, interferes with the proteasome’s ability to degrade proteins, thereby disrupting cellular processes in cancer cells, particularly multiple myeloma. It targets 20S proteasome β5 and 20S proteasome LMP7.

Molecular Weight

532.2

Molecular Formula

C₂₅H₃₂N₄O₇S

Targets

20S proteasome β5: 36 nM; 20S proteasome LMP7: 82 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 86 mg/mL (161.47 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

ONX 0912 inhibits proteasome activity, valuable in understanding cancer cell survival mechanisms.