Proteasome inhibitor PI-1840, Purity ≥98%

Synonym: 1401223-22-0; Proteasome inhibitor; PI 1840; PI1840

CAS Number: 1401223-22-0
Compound CID: 56945245

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PI-1840, soluble in DMSO and ethanol and insoluble in water, interferes with the proteasome’s ability to degrade proteins, thereby disrupting cellular processes in cancer cells, particularly multiple myeloma. It targets Chymotrypsin-like proteasome.

Molecular Weight

394.467

Molecular Formula

C₂₂H₂₆N₄O₃

Targets

Chymotrypsin-like proteasome: 27 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 77 mg/mL (195.2 mM); Water: Insoluble; Ethanol: 33 mg/mL (83.65 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

PI-1840 is used to explore its inhibitory effects on the proteasome, contributing to research in cancer and neurodegenerative diseases.