Properties
Description
Prucalopride, soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT3, 5-HT4B, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT4A.
Molecular Formula
C18H26ClN3O3
Targets
5-HT3: 3.822 μM; 5-HT4B: 8 nM; 5-HT1A: >10 μM; 5-HT1B: >10μM; 5-HT1D: >10 μM; 5-HT1E: >10μM; 5-HT1F: >10 μM; 5-HT2A: >10 μM; 5-HT2B: >10 μM; 5-HT2C: >10 μM; 5-HT4A: 2.5 nM
Solubility
DMSO: 52 mg/mL (141.35 mM); Water: insoluble; Ethanol: 33 mg/mL (89.7 mM)
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Prucalopride can be used for its effect on improving symptoms of constipation, such as infrequent bowel movements and difficulty passing stools.
Storage
Store at -20°C, and keep desiccated.
