Biological Significance of Alginate Polysaccharides

Alginate polysaccharide is a polysaccharide compound from algae and it is a linear polyacid composed mainly of α-L-alginate units. It is biocompatible biodegradable, non-toxic, and hypoallergenic to humans. Therefore, it is also applied extensively in the medical field, such as drug release systems and wound dressings. Alginate polysaccharides also affect the human immune system. When Pseudomonas aeruginosa infection enters the body, the presence of alginate polysaccharides causes the organism to be recognized by the immune system as a foreign substance and thus triggers an immune response. Therefore, an in-depth understanding of its functions and mechanisms of action is significant for understanding microbial-host interactions, developing new biomaterials, and exploring new therapeutic approaches. In addition, alginate polysaccharides have the potential to be useful in antibacterial and anticancer therapies due to their anti-inflammatory, antibacterial, and antioxidant properties.

Fig.1 Proposed structure of the alginate biosynthetic complex. (Franklin, et al., 2011)

P. aeruginosa Alginate Polysaccharide Production Services at CD BioGlyco

At CD BioGlyco, our scientific team has much experience in polysaccharides antigen production. With our various advanced technologies and Polysaccharide Vaccine Development Platform, we provide our clients with robust support for Polysaccharide Antigen Production Services. Through advanced enzymatic synthesis technology and optimized processes, we synthesize high-purity products in an efficient and controlled manner. Our services include but are not limited to the following:

• Chemical methods-based production services
  We condense the appropriate monosaccharides by chemical reactions to gradually build the structure of the polysaccharide chains. After the reaction, remove impurities and obtain the pure product by appropriate chemical conversion or purification steps.
• Enzyme-based production services
  We cultivate and collect P. aeruginosa strains, and then subject them to a cell-breaking step that allows the release of alginate polysaccharides from the cells. Subsequently, the alginate polysaccharide is broken down into polysaccharide fragments with a specific structure and biological activity by an enzymatic reaction catalyzed by alginate lyase. Finally, after the isolation and purification steps, the resulting alginate polysaccharide fragments can be used for further research and applications.

Fig.2 Enzyme-based synthesis process of P. aeruginosa alginate polysaccharide. (CD BioGlyco)

Applications

• Stabilizer for dairy and meat products
• Adsorbent material
• Nanoparticle encapsulation materials for sustained-release drugs

Advantages of Us

• High product purity
• Short production period
• Professional and customized services

CD BioGlyco offers professional P. aeruginosa alginate polysaccharide production services. Our production process is subject to strict quality control to ensure that the product meets high-quality standards. In addition, we customize the structure and properties of the synthesized products to meet the requirements of different applications. We are committed to providing sustainable, customized, and high-quality products with excellent service and competitive pricing to meet our clients' needs. Feel free to contact us for more information. 

References:

1. Franklin, M. J.; et al. Biosynthesis of the Pseudomonas aeruginosa extracellular polysaccharides, alginate, Pel, and Psl. Frontiers in microbiology. 2011, 2: 167.
2. Evans, L. R.; et al. Production and characterization of the slime polysaccharide of Pseudomonas aeruginosa. Journal of bacteriology. 1973, 116(2): 915-924.