Raf inhibitor AZ304, Purity ≥98%

Synonym: 942507-42-8; AZ304; 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide; 3-(2-Cyanopropan-2-yl)-N-[3-[(7-methoxyquinazolin-4-yl)amino]-4-methylphenyl]benzamide; Raf inhibitor

MDL: MFCD31812677
CAS Number: 942507-42-8
Compound CID: 16202218

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

AZ304, soluble in DMSO and ethanol and insoluble in water, blocks a MAPK/ERK signaling pathway. It targets BRAF V600E, BRAFWT, CRAF, and CSF1R.

Molecular Weight

451.53

Molecular Formula

C₂₇H₂₅N₅O₂

Targets

BRAF V600E: 38 nM; BRAFWT: 79 nM; CRAF: 68 nM; CSF1R: 35 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 81 mg/mL (179.39 mM); Water: Insoluble; Ethanol: 5 mg/mL (11.07 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZ304 can be used to study its selective inhibition of mutant BRAF in various cancer models.