Raf inhibitor AZ628, Purity ≥98%

Synonym: 878739-06-1; AZ 628; AZ-628; AZ628; 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide; 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide; Raf inhibitor

MDL: MFCD17392577
CAS Number: 878739-06-1
Compound CID: 11676786

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZ628, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets B-Raf, B-Raf (V600E), and C-Raf-1.

Molecular Weight

451.5

Molecular Formula

C₂₇H₂₅N₅O₂

Targets

B-Raf: 105 nM; B-Raf (V600E): 34 nM; C-Raf-1: 29 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 80 mg/mL (177.17 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZ628 can be applied to investigate BRAF and CRAF kinase activity in the MAPK signaling pathway.