Raf inhibitor AZ628, Purity ≥98%

Synonym: 878739-06-1; AZ 628; AZ-628; AZ628; 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide; 3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide; Raf inhibitor

MDL: MFCD17392577
CAS Number: 878739-06-1
Compound CID: 11676786

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZ628, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets B-Raf, B-Raf (V600E), and C-Raf-1.

Molecular Weight

451.5

Molecular Formula

C₂₇H₂₅N₅O₂

Targets

B-Raf: 105 nM; B-Raf (V600E): 34 nM; C-Raf-1: 29 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 80 mg/mL (177.17 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AZ628 can be applied to investigate BRAF and CRAF kinase activity in the MAPK signaling pathway.

Storage

Store at -20ºC.