Raf inhibitor Belvarafenib, Purity ≥98%

Synonym: Belvarafenib; 1446113-23-0; 31M3WLJ3KG; 4-Amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide; Raf inhibitor

MDL: MFCD31731098
CAS Number: 1446113-23-0
Compound CID: 89655386

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Belvarafenib, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets B-Raf, B-Raf (V600E), and CRAF.

Molecular Weight

478.93

Molecular Formula

C₂₃H₁₆ClFN₆OS

Targets

B-Raf: 56 nM; B-Raf (V600E): 7 nM; CRAF: 5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 84 mg/mL (175.39 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Belvarafenib can be utilized to study its role as a pan-RAF inhibitor in cancer research.

Storage

Store at -20ºC.