Cat. No.: X23-10-ZQ973
Raf inhibitor CEP-32496 hydrochloride, Purity ≥98%
Synonym: CEP-32496 hydrochloride; 1227678-26-3; Agerafenib hydrochloride; 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride; 8J0Y5N290S; 1-[3-(6,7-Dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea; Raf inhibitor
- CAS Number: 1227678-26-3
- Compound CID: 56954675
Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
CEP-32496 hydrochloride blocks a MAPK/ERK signaling pathway. It targets Abl1, B-Raf, B-Raf (V600E), and c-Kit.
Molecular Formula
C24H23ClF3N5O5
Targets
Abl1: 3 nM (Kd); B-Raf: 36 nM (Kd); B-Raf (V600E): 14 nM (Kd); c-Kit: 2 nM (Kd)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
CEP-32496 hydrochloride can be applied to inhibit mutant BRAF (V600E) and explore anti-cancer strategies.
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