Raf inhibitor CEP-32496, Purity ≥98%

Synonym: CEP-32496; 1188910-76-0; Agerafenib; CEP 32496; RXDX-105; 1-[3-(6,7-Dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea; Raf inhibitor

MDL: MFCD22124524
CAS Number: 1188910-76-0
Compound CID: 56846693

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CEP-32496, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets LCK, PDGFRβ, Abl1, and ALK.

Molecular Weight

517.5

Molecular Formula

C₂₄H₂₂F₃N₅O₅

Targets

LCK: 2 nM; PDGFRβ: 2 nM (Kd); Abl1: 3 nM (Kd); ALK: >10 μM (Kd)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 8 mg/mL (15.46 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

CEP-32496 can be utilized to investigate BRAF V600E inhibition and its effects on cancer cells.

Storage

Store at -20ºC.