Raf inhibitor Dabrafenib mesylate, Purity ≥98%

Synonym: Dabrafenib mesylate; 1195768-06-9; Dabrafenib (Mesylate); Taflinar; GSK 2118436B; UNII-B6DC89I63E; GSK-2118436B; Raf inhibitor

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Dabrafenib mesylate, soluble in DMSO and ethanol and insoluble in water, blocks a MAPK/ERK signaling pathway. It targets BRAF V600E and CRAF.

Molecular Weight

615.67

Molecular Formula

C₂₄H₂₄F₃N₅O₅S₃

Targets

BRAF V600E: 0.6 nM; CRAF: 5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 96 mg/mL (155.92 mM); Water: Insoluble; Ethanol: 5 mg/mL (8.12 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Dabrafenib mesylate can be used to investigate the inhibition of BRAF V600E and its therapeutic role in melanoma.

Storage

Store at -20ºC.