Raf inhibitor Dabrafenib, Purity ≥98%

Synonym: Dabrafenib; 1195765-45-7; Tafinlar; GSK2118436A; Dabrafenib (GSK2118436); Raf inhibitor

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Dabrafenib, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets B-Raf, B-Raf (V600E), and C-Raf.

Molecular Weight

519.6

Molecular Formula

C₂₃H₂₀F₃N₅O₂S₂

Targets

B-Raf: 3.2 nM; B-Raf (V600E): 0.8 nM; C-Raf: 5.0 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 28 mg/mL (53.89 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Dabrafenib can be applied to study the inhibition of BRAF V600E mutation and its therapeutic implications in melanoma.

Storage

Store at -20ºC.