Raf inhibitor Dabrafenib, Purity ≥98%

Synonym: Dabrafenib; 1195765-45-7; Tafinlar; GSK2118436A; Dabrafenib (GSK2118436); Raf inhibitor

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Dabrafenib, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets B-Raf, B-Raf (V600E), and C-Raf.

Molecular Weight

519.6

Molecular Formula

C₂₃H₂₀F₃N₅O₂S₂

Targets

B-Raf: 3.2 nM; B-Raf (V600E): 0.8 nM; C-Raf: 5.0 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 28 mg/mL (53.89 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Dabrafenib can be applied to study the inhibition of BRAF V600E mutation and its therapeutic implications in melanoma.