Raf inhibitor GW 5074, Purity ≥98%

Synonym: gw5074; 220904-83-6; GW 5074; GW-5074; Raf1 Kinase Inhibitor I; 1233748-60-1; 5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone; Raf inhibitor

MDL: MFCD09971042
CAS Number: 220904-83-6
Compound CID: 5924208

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GW 5074, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets C-Raf.

Molecular Weight

520.94

Molecular Formula

C₁₅H₈Br₂INO₂

Targets

C-Raf: 9 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 101 mg/mL (193.87 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GW 5074 can be utilized to inhibit Raf-1 kinase and study its role in the MAPK/ERK pathway.