Raf inhibitor L-779450, Purity ≥98%

Synonym: 303727-31-3; L-779450; 2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol; L-779,450; L779450; 2-Chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol; Raf inhibitor

MDL: MFCD12828750
CAS Number: 303727-31-3
Compound CID: 9950176

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

L-779450, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets B-Raf.

Molecular Weight

347.8

Molecular Formula

C₂₀H₁₄ClN₃O

Targets

B-Raf: 2.4 nM (Kd)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 62 mg/mL (178.26 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

L-779450 can be used to study selective inhibition of protein kinases in signal transduction pathways.

Storage

Store at -20ºC.