Raf inhibitor Lifirafenib, Purity ≥98%

Synonym: lifirafenib; Beigene-283; BGB-283; 1446090-79-4; 1446090-77-2; BGB283; Lifirafenib [USAN]; Raf inhibitor

CAS Number: 1446090-79-4
Compound CID: 89670174

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

Lifirafenib, soluble in DMSO and ethanol and insoluble in water, blocks a MAPK/ERK signaling pathway. It targets BRAF V600E, EGFR, and EGFR (L858R/T790M).

Molecular Weight

478.42

Molecular Formula

C₂₅H₁₇F₃N₄O₃

Targets

BRAF V600E: 23 nM; EGFR: 29 nM; EGFR (L858R/T790M): 495 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 86 mg/mL (179.76 mM); Water: Insoluble; Ethanol: 86 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

Lifirafenib can be investigated for its potential to inhibit both RAF and EGFR kinases in tumor cells.