Raf inhibitor Lifirafenib, Purity ≥98%

Synonym: lifirafenib; Beigene-283; BGB-283; 1446090-79-4; 1446090-77-2; BGB283; Lifirafenib [USAN]; Raf inhibitor

CAS Number: 1446090-79-4
Compound CID: 89670174

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Lifirafenib, soluble in DMSO and ethanol and insoluble in water, blocks a MAPK/ERK signaling pathway. It targets BRAF V600E, EGFR, and EGFR (L858R/T790M).

Molecular Weight

478.42

Molecular Formula

C₂₅H₁₇F₃N₄O₃

Targets

BRAF V600E: 23 nM; EGFR: 29 nM; EGFR (L858R/T790M): 495 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 86 mg/mL (179.76 mM); Water: Insoluble; Ethanol: 86 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Lifirafenib can be investigated for its potential to inhibit both RAF and EGFR kinases in tumor cells.

Storage

Store at -20ºC.