Raf inhibitor LXH254, Purity ≥98%

Synonym: LXH254; Naporafenib; 1800398-38-2; LXH-254; N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide; LXH254 free base; Raf inhibitor

CAS Number: 1800398-38-2
Compound CID: 90456533

Product Size

2 mg; 5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

MSDS

Properties

Description

LXH254, soluble in DMSO and ethanol and insoluble in water, blocks a MAPK/ERK signaling pathway. It targets Abl1, ARAF, B-Raf, and CRAF.

Molecular Weight

502.49

Molecular Formula

C₂₅H₂₅F₃N₄O₄

Targets

Abl1: 4.9 μM; ARAF: 6.4 nM; B-Raf: 0.21 nM; CRAF: 0.072 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 85 mg/mL (169.15 mM); Water: Insoluble; Ethanol: 29 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

LXH254 can be utilized to explore its dual inhibition of BRAF and CRAF in cancer models.