Raf inhibitor LXH254, Purity ≥98%

Synonym: LXH254; Naporafenib; 1800398-38-2; LXH-254; N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide; LXH254 free base; Raf inhibitor

CAS Number: 1800398-38-2
Compound CID: 90456533

Product Size

2 mg; 5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LXH254, soluble in DMSO and ethanol and insoluble in water, blocks a MAPK/ERK signaling pathway. It targets Abl1, ARAF, B-Raf, and CRAF.

Molecular Weight

502.49

Molecular Formula

C₂₅H₂₅F₃N₄O₄

Targets

Abl1: 4.9 μM; ARAF: 6.4 nM; B-Raf: 0.21 nM; CRAF: 0.072 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 85 mg/mL (169.15 mM); Water: Insoluble; Ethanol: 29 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

LXH254 can be utilized to explore its dual inhibition of BRAF and CRAF in cancer models.

Storage

Store at -20ºC.