Raf inhibitor LY3009120, Purity ≥98%

Synonym: LY3009120; 1454682-72-4; LY-3009120; DP-4978; 1-(3,3-Dimethylbutyl)-3-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea; Raf inhibitor

CAS Number: 1454682-72-4
Compound CID: 71721540

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LY3009120, soluble in warmed DMSO and insoluble in water and ethanol, blocks a MAPK/ERK signaling pathway. It targets B-Raf, B-Raf (V600E), and CRAF.

Molecular Weight

424.51

Molecular Formula

C₂₃H₂₉FN₆O

Targets

B-Raf: 9.1 nM; B-Raf (V600E): 5.8 nM; CRAF: 15 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 3 mg/mL (7.06 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

LY3009120 can be used to investigate the inhibition of pan-RAF kinases in cancer research.

Storage

Store at -20ºC.