Raf inhibitor NVP-BHG712, Purity ≥98%

Synonym: NVP-BHG712; 940310-85-0; 4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide; Raf inhibitor

MDL: MFCD20272929
CAS Number: 940310-85-0
Compound CID: 16747388

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

NVP-BHG712, soluble in DMSO and ethanol and insoluble in water, blocks a MAPK/ERK signaling pathway. It targets C-Raf, c-Src, Axl, and c-Abl.

Molecular Weight

503.5

Molecular Formula

C₂₆H₂₀F₃N₇O

Targets

C-Raf: 0.395 μM; c-Src: 1.266 μM; Axl: >10 μM; c-Abl: 1.667 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 90 mg/mL (178.75 mM); Water: Insoluble; Ethanol: 3 mg/mL (5.95 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

NVP-BHG712 can be used to inhibit EphB4 kinase in research focused on cancer and angiogenesis.