Raf inhibitor PLX-4720, Purity ≥98%

Synonym: 918505-84-7; PLX-4720; PLX4720; N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide; PLX 4720; N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide; N-[3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide; Raf inhibitor

MDL: MFCD14635203
CAS Number: 918505-84-7
Compound CID: 24180719

Product Size

1 mg; 2 mg; 5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PLX-4720, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets BRAF V600E, BRK, Aurora A, and B-Raf.

Molecular Weight

413.8

Molecular Formula

C₁₇H₁₄ClF₂N₃O₃S

Targets

BRAF V600E: 13 nM; BRK: 130 nM; Aurora A: 3.4 μM; B-Raf: 160 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 81 mg/mL (195.73 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

PLX-4720 is employed in studies to investigate the selective inhibition of the BRAFV600E mutant kinase in melanoma and other cancers.