Raf inhibitor PLX4032, Purity ≥98%

Synonym: Vemurafenib; 918504-65-1; PLX4032; Zelboraf; 1029872-54-5; PLX-4032; N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide; Raf inhibitor

MDL: MFCD18074504
CAS Number: 918504-65-1
Compound CID: 42611257

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PLX4032, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets ACK1, B-Raf (V600E), B-Raf, and BLK.

Molecular Weight

489.9

Molecular Formula

C₂₃H₁₈ClF₂N₃O₃S

Targets

ACK1: 19 nM; B-Raf (V600E): 31 nM; B-Raf: 100 nM; BLK: 547 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 83 mg/mL (169.41 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

PLX4032 can be utilized to study BRAF V600E and associated melanoma treatments by inhibiting mutant BRAF.

Storage

Store at -20ºC.