Raf inhibitor PLX4032, Purity ≥98%

Synonym: Vemurafenib; 918504-65-1; PLX4032; Zelboraf; 1029872-54-5; PLX-4032; N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide; Raf inhibitor

MDL: MFCD18074504
CAS Number: 918504-65-1
Compound CID: 42611257

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PLX4032, soluble in DMSO and insoluble in ethanol and water, blocks a MAPK/ERK signaling pathway. It targets ACK1, B-Raf (V600E), B-Raf, and BLK.

Molecular Weight

489.9

Molecular Formula

C₂₃H₁₈ClF₂N₃O₃S

Targets

ACK1: 19 nM; B-Raf (V600E): 31 nM; B-Raf: 100 nM; BLK: 547 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 83 mg/mL (169.41 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

PLX4032 can be utilized to study BRAF V600E and associated melanoma treatments by inhibiting mutant BRAF.