Properties
Description
RAF mutant-IN-1 blocks a MAPK/ERK signaling pathway. It targets BRAF V600E, BRAFWT, and C-RAF 340D/Y341D.
Molecular Formula
C23H18Cl3FN6O2S
Targets
BRAF V600E: 30 nM; BRAFWT: 392 nM; C-RAF 340D/Y341D: 21 nM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
RAF mutant-IN-1 can be employed to examine its selectivity and efficacy in inhibiting mutant RAF in cancer research.