Raf inhibitor RAF265, Purity ≥98%

Synonym: RAF265; 927880-90-8; CHIR-265; RAF-265; RAF 265; RAF265(CHIR-265); RAF265 (CHIR-265); Raf inhibitor

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

RAF265, soluble in DMSO and ethanol and insoluble in water, blocks a MAPK/ERK signaling pathway. It targets B-Raf and VEGFR2.

Molecular Weight

518.4

Molecular Formula

C₂₄H₁₆F₆N₆O

Targets

B-Raf: 3-60 nM; VEGFR2: 30 nM (EC₅₀)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 85 mg/mL (163.96 mM); Water: Insoluble; Ethanol: 28 mg/mL (54.01 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

RAF265 can be used to investigate the inhibition of both RAF and VEGFR in cancer models.