Raf inhibitor RAF265, Purity ≥98%

Synonym: RAF265; 927880-90-8; CHIR-265; RAF-265; RAF 265; RAF265(CHIR-265); RAF265 (CHIR-265); Raf inhibitor

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

RAF265, soluble in DMSO and ethanol and insoluble in water, blocks a MAPK/ERK signaling pathway. It targets B-Raf and VEGFR2.

Molecular Weight

518.4

Molecular Formula

C₂₄H₁₆F₆N₆O

Targets

B-Raf: 3-60 nM; VEGFR2: 30 nM (EC₅₀)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 85 mg/mL (163.96 mM); Water: Insoluble; Ethanol: 28 mg/mL (54.01 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

RAF265 can be used to investigate the inhibition of both RAF and VEGFR in cancer models.

Storage

Store at -20ºC.