Raf inhibitor Sorafenib tosylate, Purity ≥98%

Synonym: Sorafenib tosylate; 475207-59-1; Nexavar; Nexavar(R); Sorafenib tosylate [USAN]; Sorafenib (Tosylate); Raf inhibitor

MDL: MFCD08235032
CAS Number: 475207-59-1
Compound CID: 406563

Product Size

1 mg; 2 mg; 5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Sorafenib tosylate, soluble in DMSO and water and insoluble in ethanol, blocks a MAPK/ERK signaling pathway. It targets B-Raf, VEGFR2/Flk1, B-Raf (V599E), and c-Kit.

Molecular Weight

637

Molecular Formula

C₂₁H₁₆ClF₃N₄O₃.C₇H₈O₃S

Targets

B-Raf: 22 nM; VEGFR2/Flk1: 15 nM; B-Raf (V599E): 38 nM; c-Kit: 68 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 114 mg/mL (178.95 mM); Water: <1 mg/mL; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Sorafenib tosylate is widely used in cancer research for its ability to inhibit multiple kinases, including RAF kinase.