Raf inhibitor Sorafenib tosylate, Purity ≥98%

Synonym: Sorafenib tosylate; 475207-59-1; Nexavar; Nexavar(R); Sorafenib tosylate [USAN]; Sorafenib (Tosylate); Raf inhibitor

MDL: MFCD08235032
CAS Number: 475207-59-1
Compound CID: 406563

Product Size

1 mg; 2 mg; 5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Sorafenib tosylate, soluble in DMSO and water and insoluble in ethanol, blocks a MAPK/ERK signaling pathway. It targets B-Raf, VEGFR2/Flk1, B-Raf (V599E), and c-Kit.

Molecular Weight

637

Molecular Formula

C₂₁H₁₆ClF₃N₄O₃.C₇H₈O₃S

Targets

B-Raf: 22 nM; VEGFR2/Flk1: 15 nM; B-Raf (V599E): 38 nM; c-Kit: 68 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 114 mg/mL (178.95 mM); Water: <1 mg/mL; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Sorafenib tosylate is widely used in cancer research for its ability to inhibit multiple kinases, including RAF kinase.

Storage

Store at -20ºC.