Ras inhibitor APS-2-79 HCl, Purity ≥98%

Synonym: 2002381-31-7; KSR/Ras inhibitor; Ras inhibitor

CAS Number: 2002381-31-7
Compound CID: 122177134

Product Size

5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

APS-2-79 HCl, soluble in DMSO and ethanol and insoluble in water, blocks the activity of Ras proteins, which play a key role in cell signal transduction and are frequently implicated in oncogenic mutations. It targets KSR2.

Molecular Weight

423.89

Molecular Formula

C₂₃H₂₁N₃O₃.HCl

Targets

KSR2: 120 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 82 mg/mL (193.44 mM); Water: Insoluble; Ethanol: 27 mg/mL (63.69 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

APS-2-79 HCl can be utilized as an allosteric inhibitor of the KRAS interaction with SOS.

Storage

Store at -20ºC.