Properties
Description
ARS-1620, soluble in DMSO and ethanol and insoluble in water, blocks the activity of Ras proteins, which play a key role in cell signal transduction and are frequently implicated in oncogenic mutations.
Molecular Formula
C21H17ClF2N4O2
Solubility
DMSO: 82 mg/mL (190.33 mM); Water: Insoluble; Ethanol: 57 mg/mL (132.3 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
ARS-1620 can be used to selectively inhibit KRAS G12C in preclinical cancer models.
