Properties
Description
ARS-853, soluble in warmed DMSO and warmed ethanol and insoluble in water, blocks the activity of Ras proteins, which play a key role in cell signal transduction and are frequently implicated in oncogenic mutations. It targets KRAS(G12C).
Molecular Formula
C22H29ClN4O3
Targets
KRAS(G12C): 2.5 μM
Solubility
Warmed DMSO: 80 mg/mL (184.78 mM); Water: Insoluble; Warmed ethanol: 1 mg/mL (2.3 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
ARS-853 can be used to study selective inhibition of KRAS G12C for targeted cancer therapy.
