Properties
Description
BQU57, soluble in warmed DMSO and warmed ethanol and insoluble in water, blocks the activity of Ras proteins, which play a key role in cell signal transduction and are frequently implicated in oncogenic mutations.
Molecular Formula
C16H13F3N4O
Solubility
Warmed DMSO: 58 mg/mL (173.6 mM); Water: Insoluble; Warmed ethanol: 18 mg/mL (53.87 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
BQU57 can be used to target KRAS-driven cancers by inhibiting the interaction between KRAS and related effector proteins.
