Properties
Description
EHT 1864, soluble in warmed DMSO and water and insoluble in ethanol, blocks the activity of Ras proteins, which play a key role in cell signal transduction and are frequently implicated in oncogenic mutations. It targets Rac1, Rac1b, Rac2, and Rac3.
Molecular Formula
C25H27F3N2O4S.2HCl
Targets
Rac1: 40 nM (Kd); Rac1b: 50 nM (Kd); Rac2: 60 nM (Kd); Rac3: 250 nM (Kd)
Solubility
Warmed DMSO: 90 mg/mL (154.77 mM); Water: 90 mg/mL (154.77 mM); Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
EHT 1864 can be employed to study inhibition of Rac1 in cellular processes and cancer metastasis.
