Properties
Description
EHT 1864, soluble in warmed DMSO and water and insoluble in ethanol, blocks the activity of Ras proteins, which play a key role in cell signal transduction and are frequently implicated in oncogenic mutations. It targets Rac1, Rac1b, Rac2, and Rac3.
Molecular Formula
C25H27F3N2O4S.2HCl
Targets
Rac1: 40 nM (Kd); Rac1b: 50 nM (Kd); Rac2: 60 nM (Kd); Rac3: 250 nM (Kd)
Solubility
Warmed DMSO: 90 mg/mL (154.77 mM); Water: 90 mg/mL (154.77 mM); Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
EHT 1864 can be employed to study inhibition of Rac1 in cellular processes and cancer metastasis.
