Properties
Description
ZCL-278, soluble in DMSO and insoluble in ethanol and water, blocks the activity of Ras proteins, which play a key role in cell signal transduction and are frequently implicated in oncogenic mutations. It targets Cdc42 GTPase.
Molecular Formula
C21H19BrClN5O4S2
Targets
Cdc42 GTPase: 11.4 μM(Kd)
Solubility
DMSO: 99 mg/mL (169.26 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
ZCL-278 can be used to study inhibition of Cdc42, a Rho GTPase, in cellular signaling.