Ribonucleotide reductase inhibitor, Triapine, Purity ≥98%

Synonym: 200933-27-3; 3-AP; 2-((3-Aminopyridin-2-yl)methylene)hydrazinecarbothioamide; PAN-811; 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone; [(E)-(3-Aminopyridin-2-yl)methylideneamino]thiourea; Ribonucleotide reductase inhibitor

MDL: MFCD00924747
CAS Number: 200933-27-3
Compound CID: 9571836

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Triapine, soluble in DMSO and insoluble in water and ethanol, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting ribonucleotide reductase. The molecular weight of the compound is 195.24, and its molecular formula is C₇H₉N₅S.

Molecular Weight

195.24

Molecular Formula

C₇H₉N₅S

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 17 mg/mL (87.07 mM); Water: insoluble; Ethanol: insoluble; In vivo: 5% DMSO + 40% PEG300 + 5% Tween80 + 50% ddH₂O, 1.18 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

Triapine plays a key role in disrupting DNA synthesis in rapidly dividing tumor cells.