RO-1138452

Synonym: 221529-58-4; CAY-10441

CAS Number: 221529-58-4
Compound CID: 9839644

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

RO-1138452, soluble in DMSO and ethanol and insoluble in water, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets guinea-pig 5-HT4 receptor, human α2A adrenoceptor, human α2A adrenoceptor, human 5-HT1A receptor, human 5-HT1A receptor, human muscarinic M1 receptor, human muscarinic M1 receptor, human muscarinic M2 receptor, human muscarinic M2 receptor, and human muscarinic M4 receptor.

Molecular Weight

309.41

Molecular Formula

C₁₉H₂₃N₃O

Targets

Guinea-pig 5-HT4 receptor: 8910 nM; Guinea-pig 5-HT4 receptor: 5.35 (pKi); Human α2A adrenoceptor: 724 nM; Human α2A adrenoceptor: 6.49 (pKi); Human 5-HT1A receptor: 8580 nM; Human 5-HT1A receptor: 5.37 (pKi); Human muscarinic M1 receptor: 2570 nM; Human muscarinic M1 receptor: 5.66 (pKi); Human muscarinic M2 receptor: 2220 nM; Human muscarinic M2 receptor: 5.88 (pKi); Human Muscarinic M4 receptor: 1450 nM

Form

Lyophilized powder

Purity

>98%

Solubility

DMSO: 58 mg/mL (187.45 mM); Water: insoluble; Ethanol: 58 mg/mL (187.45 mM)

Applications

RO-1138452 can be used to research and develop therapeutic strategies for certain diseases that involve excessive activation of GPCR-G protein signaling pathways.