Ro 31-8220

Synonym: 125314-64-9; Bisindolylmaleimide IX; Ro31-8220

CAS Number: 125314-64-9
PubChem CID: 5083

Product Size

1 mg; 5 mg; 10 mg; 50 mg

Price

Datasheet

MSDS

Properties

Description

Ro 31-8220 blocks the function of Smad proteins in the TGF-β signaling pathway. It targets GSK3β, MAPKAP-K1b, MSK1, PKC-α, PKC-βI, PKC-βII, PKC-ε, PKC-γ, rat brain PKC, and S6K1.

Molecular Weight

457.55

Molecular Formula

C₂₅H₂₃N₅O₂S

Targets

GSK3β: 38 nM; MAPKAP-K1b: 3 nM; MSK1: 8 nM; PKC-α: 5 nM; PKC-βI: 24 nM; PKC-βII: 14 nM; PKC-ε: 24 nM; PKC-γ: 27 nM; Rat brain PKC: 23 nM; S6K1: 15 nM

Form

Lyophilized powder

Purity

Applications

Ro 31-8220 can be used to inhibit abnormal mast cell proliferation and reduce symptoms associated with mast cell activation, such as skin lesions, gastrointestinal disturbances, and anaphylaxis.