Properties
Description
Ro 31-8220 blocks the function of Smad proteins in the TGF-β signaling pathway. It targets GSK3β, MAPKAP-K1b, MSK1, PKC-α, PKC-βI, PKC-βII, PKC-ε, PKC-γ, rat brain PKC, and S6K1.
Molecular Formula
C25H23N5O2S
Targets
GSK3β: 38 nM; MAPKAP-K1b: 3 nM; MSK1: 8 nM; PKC-α: 5 nM; PKC-βI: 24 nM; PKC-βII: 14 nM; PKC-ε: 24 nM; PKC-γ: 27 nM; Rat brain PKC: 23 nM; S6K1: 15 nM
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Ro 31-8220 can be used to inhibit abnormal mast cell proliferation and reduce symptoms associated with mast cell activation, such as skin lesions, gastrointestinal disturbances, and anaphylaxis.
Storage
Store at -20℃, and keep desiccated.
