Properties
Description
Ro 31-8220 mesylate, soluble in DMSO and insoluble in water and ethanol, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets PKCα, PKCβ1, PKCβ2, PKCε, and PKCγ.
Molecular Formula
C25H23N5O2S·CH3SO3H
Targets
PKCα: 5 nM; PKCβ1: 24 nM; PKCβ2: 14 nM; PKCε: 24 nM; PKCγ: 27 nM
Solubility
DMSO: 85 mg/mL (153.52 mM); Water: insoluble; Ethanol: insoluble
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Ro 31-8220 mesylate can be used to help develop potential therapeutic strategies for certain diseases, such as inflammatory disease, fibrotic diseases, and cancer.
Storage
Store at -20℃, and keep desiccated.
