Ro 31-8220 mesylate

Synonym: 138489-18-6; BIM IX; Bisindolylmaleimide IX (mesylate)

CAS Number: 138489-18-6
PubChem CID: 11628205

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Ro 31-8220 mesylate, soluble in DMSO and insoluble in water and ethanol, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets PKCα, PKCβ1, PKCβ2, PKCε, and PKCγ.

Molecular Weight

553.7

Molecular Formula

C₂₅H₂₃N₅O₂S·CH₃SO₃H

Targets

PKCα: 5 nM; PKCβ1: 24 nM; PKCβ2: 14 nM; PKCε: 24 nM; PKCγ: 27 nM

Form

Lyophilized powder

Purity

>98%

Solubility

DMSO: 85 mg/mL (153.52 mM); Water: insoluble; Ethanol: insoluble

Applications

Ro 31-8220 mesylate can be used to help develop potential therapeutic strategies for certain diseases, such as inflammatory disease, fibrotic diseases, and cancer.