ROCK inhibitor AT13148, Purity ≥98%

Synonym: 1056901-62-2; AT 13148; AT-13148; ROCK inhibitor

CAS Number: 1056901-62-2
Compound CID: 24905401

Product Size

5 mg; 10 mg; 25 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AT13148, soluble in DMSO and insoluble in ethanol and water, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets ROCK1, ROCK2, Akt1, and Akt2.

Molecular Weight

313.78

Molecular Formula

C₁₇H₁₆ClN₃O

Targets

ROCK1: 6 nM; ROCK2: 4 nM; Akt1: 38 nM; Akt2: 402 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 55 mg/mL (175.28 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AT13148 is used to examine its role as a multi-AGC kinase inhibitor in cancer research.