ROCK inhibitor Fasudil HCl, Purity ≥98%

Synonym: Fasudil hydrochloride; 105628-07-7; Fasudil HCl; Eril; Fasudil (HA-1077) HCl; 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride; Fasudil (Hydrochloride); ROCK inhibitor

MDL: MFCD00943198
CAS Number: 105628-07-7
Compound CID: 163751

Product Size

250 mg; 500 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Fasudil HCl, soluble in DMSO and water and insoluble in ethanol, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets MLCK, PKA, PKC, PKG, and ROCK2.

Molecular Weight

327.8

Molecular Formula

C₁₄H₁₇N₃O₂S.HCl

Targets

MLCK: 36 μM (Ki); PKA: 1.6 μM (Ki); PKC: 3.3 μM (Ki); PKG: 1.6 μM (Ki); ROCK2: 330 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 5 mg/mL (15.25 mM); Water: 60 mg/mL (183.02 mM); Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Fasudil HCl can be used to examine its role as a Rho kinase inhibitor and its potential therapeutic applications in cardiovascular diseases and neurological disorders.

Storage

Store at -20ºC.