Properties
Description
Fasudil HCl, soluble in DMSO and water and insoluble in ethanol, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets MLCK, PKA, PKC, PKG, and ROCK2.
Molecular Formula
C14H17N3O2S.HCl
Targets
MLCK: 36 μM (Ki); PKA: 1.6 μM (Ki); PKC: 3.3 μM (Ki); PKG: 1.6 μM (Ki); ROCK2: 330 nM (Ki)
Solubility
DMSO: 5 mg/mL (15.25 mM); Water: 60 mg/mL (183.02 mM); Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Fasudil HCl can be used to examine its role as a Rho kinase inhibitor and its potential therapeutic applications in cardiovascular diseases and neurological disorders.