Properties
Description
GSK 269962 blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets AKT1, AKT2, AKT3, and CDK2.
Molecular Formula
C29H30N8O5
Targets
AKT1: 955 nM; AKT2: 1350 nM; AKT3: 1510 nM; CDK2: 3500 nM
Identity
Confirmed by NMR/HPLC/MS.
Applications
GSK 269962 is utilized to study its inhibitory effects on Rho-associated protein kinases (ROCK1/2) in cell mobility research.