ROCK inhibitor GSK429286A, Purity ≥98%

Synonym: GSK429286A; 864082-47-3; RHO-15; N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide; N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide; ROCK inhibitor

MDL: MFCD16618404
CAS Number: 864082-47-3
Compound CID: 11373846

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GSK429286A, soluble in DMSO and ethanol and insoluble in water, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets ROCK1 and ROCK2.

Molecular Weight

432.4

Molecular Formula

C₂₁H₁₆F₄N₄O₂

Targets

ROCK1: 14 nM; ROCK2: 63 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 81 mg/mL (187.33 mM); Water: Insoluble; Ethanol: 4 mg/mL (9.25 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

GSK429286A can be used to investigate its inhibitory effects on Rho kinase and its implications in treating cardiovascular and fibrotic diseases.

Storage

Store at -20ºC.