Properties
Description
GSK429286A, soluble in DMSO and ethanol and insoluble in water, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets ROCK1 and ROCK2.
Molecular Formula
C21H16F4N4O2
Targets
ROCK1: 14 nM; ROCK2: 63 nM
Solubility
DMSO: 81 mg/mL (187.33 mM); Water: Insoluble; Ethanol: 4 mg/mL (9.25 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
GSK429286A can be used to investigate its inhibitory effects on Rho kinase and its implications in treating cardiovascular and fibrotic diseases.