ROCK inhibitor GSK429286A, Purity ≥98%

Synonym: GSK429286A; 864082-47-3; RHO-15; N-(6-Fluoro-1H-indazol-5-yl)-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1H-pyridine-5-carboxamide; N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide; ROCK inhibitor

MDL: MFCD16618404
CAS Number: 864082-47-3
Compound CID: 11373846

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

GSK429286A, soluble in DMSO and ethanol and insoluble in water, blocks the ATP-binding site of ROCK, thereby inhibiting its kinase activity. It targets ROCK1 and ROCK2.

Molecular Weight

432.4

Molecular Formula

C₂₁H₁₆F₄N₄O₂

Targets

ROCK1: 14 nM; ROCK2: 63 nM

Form

Lyophilized powder

Purity

Solubility

DMSO: 81 mg/mL (187.33 mM); Water: Insoluble; Ethanol: 4 mg/mL (9.25 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

GSK429286A can be used to investigate its inhibitory effects on Rho kinase and its implications in treating cardiovascular and fibrotic diseases.